Since classical antiquity, science as a type of knowledge has been closely linked to philosophy. In the early modern period the words "science" and "philosophy of nature" were sometimes used interchangeably. By the 17th century, natural philosophy (which is today called "natural science") was considered a separate branch of philosophy.

In modern usage, "science" most often refers to a way of pursuing knowledge, not only the knowledge itself. It is also often restricted to those branches of study that seek to explain the phenomena of the material universe. In the 17th and 18th centuries scientists increasingly sought to formulate knowledge in terms of laws of nature such as Newton's laws of motion. And over the course of the 19th century, the word "science" became increasingly associated with the scientific method itself, as a disciplined way to study the natural world, including physics, chemistry, geology and biology. It is in the 19th century also that the term scientist was created by the naturalist-theologian William Whewell to distinguish those who sought knowledge on nature from those who sought other types of knowledge.

However, "science" has also continued to be used in a broad sense denoting reliable, teachable knowledge about a topic, as in modern terms like library science or computer science. This is also reflected in the names of some areas of academic study such as "social science" or "political science".